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Age category (years)
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|---|
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Total
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< 1
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1–4
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≥ 5
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|---|
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N (%)
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308 (100)
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13 (4.2)
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176 (57.1)
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119 (38.6)
|
|
Sex, Female, n (%)
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161 (52.3)
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8 (61.5)
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92 (52.3)
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61 (51.3)
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Underweightb (WAZ < − 2.00), n/N (%)
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28/190 (14.7)a
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0 (0.0)
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26 (13.6)
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2
|
|
Axillary temperature (oC), mean (SD)
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38.0 (1.1)
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38.3 (0.8)
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38.1 (1.1)
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37.7 (1.2)
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Haemoglobin (g/dL), mean (SD)
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10.0 (1.9)
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8.5 (1.3)
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9.5 (1.8)
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11.0 (1.8)
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Moderate- to- severe anaemia patients (Hb < 8.0 g/dL), n (%)
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47 (15.3)
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5 (38.5)
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37 (21.0)
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5 (4.2)
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Severe anaemia (Hb < 6.0 g/dL), n (%)
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4 (1.3)
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0 (0)
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4 (2.3)
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0(0)
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Geometric mean parasite density, (95% CI)
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27,594 (23,737–32,079)
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15,879 (5871–42,945)
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34,921 (28,916–42,172)
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20,692 (16,184–26,455)
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Parasite density ≥ 100,000, n (%)
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47 (15.3)
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3 (23.1)
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32 (18.2)
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12 (10.1)
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Gametocyte Prevalence, n (%)
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9 (2.9)
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1 (7.7)
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6 (3.4)
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2 (1.7)
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Total Dose (mg/ kg), median (IQR); range
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31.2 (26.1–38.9) 7.6–52.6
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25.3 (23.8–25.3) 13.4–31.15
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33.8 (27.0–39.7) 14.5–45.0
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33.8 (25.3–38.6) 7.2–52.6
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|
D0 AQ concentration > LLOQ, n (%)
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64 (20.8)
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0(0)
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45 (25.6)
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19 (16.0)
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- N = Sample population, n = number of patients in category, WAZ = weight-for-age Z-score, sd = standard deviation, Hb = haemoglobin concentration, CI = confidence interval, mg/kg = milligram per kilogram, IQR = interquartile range, D0 = Day 0 pre-dose, AQ = amodiaquine, BLQ = below the limit of quantification
- a Two patients aged 5 years
- bWAZ score only calculated for children ≤ 5 years; 2/13 (15.4%) children aged 5 years had WAZ score < − 2.00
