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Parameter
Age category (years)
p-value
All ages
< 1
1–4
≥ 5
n = 223
n = 9
n = 125
n = 89
Amodiaquine
AUC0-∞ (ng h /ml)
1318 (583–3549)
4201 (2773–17,909)
1994 (642–5199)
875 (400–1,434)
< 0.001
Cmax (ng/ml)
18.8 (9.8–50.7)
49.6 (21.7–107.0)
27.7 (14.7–70.0)
11.6 (6.7–18.8)
< 0.001
Tmax (days)
2 (1–3)
1 (1–2)
2 (1–3)
2 (1–3)
0.71
Cl/F (L kg−1 h−1 )
25.9 (8.6–56.0)
6.7 (1.4–11.2)
15.7 (7.0–47.1)
39.6 (18.7–76.9)
< 0.001
Vd/F (L kg−1 )
1,195 (416–2,735)
325 (98–1141)
859 (359–2,613)
1,840 (861–3,656)
0.008
t½ (hours)
47.4 (32.4–72.8)
54.1 (24.6–148.7)
48.8 (32.6–87.9)
41.7 (32.4–56.1)
0.24
n = 227
n = 9
n = 127
n = 91
Desethylamodiaquine
AUC0-∞ (ng h /ml)
116,100 (70,325–203,110)
163,020 (94,262–255,562)
124,508 (79,736–225,582)
105,596 (56,986–159,382)
0.057
Cmax (ng/ml)
565 (349–827)
365 (266–665)
604 (377–937)
528 (260–720)
0.046
Tmax (days)
3 (2–3)
2 (2–3)
3 (2–3)
3 (2–3)
0.33
Cl/F(L kg−1 h−1 )
0.26 (0.16–0.46)
0.19 (0.11–0.31)
0.24 (0.16–0.41)
0.31 (0.16–0.56)
0.071
Vd/F (L kg−1 )
67.5 (43.0–126.8)
57.0 (40.1–100.5)
62.3 (42.9–124.6)
72.9 (45.3–150.2)
0.49
t ½ (hours)
196.4 (152.8–276.1)
237.8 (204.6–280.3)
187.6 (155.1–276.1)
200.1 (137.5–268.6)
0.60
IQR Interquartile range, AUC0-∞ Area under the concentration versus time curve from time zero to infinity, ng.h /ml nanogram hour per milliliter, Cmax = Observed maximum concentration, ng/ml nanogram per milliliter, Tmax time to maximum concentration, CL/f apparent clearance, Vd/f apparent volume of distribution, t½ = elimination half-life
