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Table 2 Comparison of qRT-PCR SBP-1 prevalence between SP–AQ and DP treatment arms over time

From: Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians

Visit SBP-1 qRT-PCR Microscopy
Prevalence, n (%) DP: SP–AQ
PR [95% CI] 		p-value1 Prevalence, n (%) DP: SP–AQ
PR [95% CI] 		p-value1
All SP–AQ DP All SP–AQ DP DP
Day 0 64 (89) 31 (89) 33 (89) 1.01 [0.86, 1.19] 0.93 43 (59) 24 (67) 19 (51) 0.77 [0.52, 1.14] 0.18
Day 1 54 (75) 29 (81) 25 (69) 0.86 [0.66, 1.13] 0.28 19 (26) 16 (44) 3 (8) 0.18 [0.05, 0.57] 0.0004
Day 2 45 (63) 25 (71) 20 (54) 0.76 [0.53, 1.09] 0.13 9 (12) 6 (17) 3 (8) 0.49 [0.13, 1.80] 0.27
Day 7 19 (26) 9 (25) 10 (27) 1.08 [0.50, 2.35] 0.84 1 (1) 0 (0) 1 (3) – –
Day 14 14 (19) 7 (19) 7 (19) 0.98 [0.38, 2.50] 0.96 1 (1) 1 (3) 0 (0) – –
Day 28 8 (11) 6 (17) 2 (5) 0.32 [0.07, 1.50] 0.15 1 (1) 1 (3) 0 (0) – –
Day 42 24 (33) 18 (50) 6 (17) 0.33 [0.15, 0.74] 0.0027 7 (11) 4 (11) 3 (8) 0.75 [0.18, 3.11] 0.69
  1. PR prevalence ratio, SP–AQ sulfadoxine–pyrimethamine and amodiaquine, DP dihydroartemisinin–piperaquine
  2. 1 p-values computed using Chi-squared test or Fisher’s exact test if any cell value in 2 × 2 table was less than five
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Malaria Journal

ISSN: 1475-2875

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