Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians

Table 3 Comparison of SBP-1 parasite density between DP and SP-AQ arms

Visit	Median density (per μL) [IQR]		Difference in log₁₀ SBP-1 Density
Visit	SP-AQ	DP	DP:SP-AQ MD [95% CI]¹	DP:SP-AQ % Difference [95% CI]²	p-value
Day 0	891.3 [8.2, 2065.4]	330.4 [6.5, 1990.7]	0.01 [− 1.0, 1.0]	3 [− 91, 1019]	0.98
Day 1	21.2 [0.6, 212]	0.6 [0, 2.3]	− 1.5 [− 2.0, − 0.9]	− 97 [− 99, − 89]	< 0.001
Day 2	0.6 [0, 11.2]	0.02 [0, 0.3]	− 1.2 [− 1.8, − 0.6]	− 94 [− 98, 76]	< 0.001
Day 7	0 [0, 0.003]	0 [0, 0.07]	0.09 [− 0.4, 0.6]	24 [− 64, 320]	0.73
Day 14	0 [0, 0]	0 [0, 0]	− 0.3 [− 0.8, 0.3]	− 44 [− 84, 96]	0.36
Day 28	0 [0, 0]	0 [0, 0]	− 0.4 [− 0.8, 0.08]	− 57 [− 85, 19]	0.10
Day 42	0.03 [0, 7.1]	0 [0, 0]	− 1.2 [− 2.1, − 0.3]	− 94 [− 99, − 46]	0.012

IQR interquartile range
¹ Coefficient from linear regression modelling log10 SBP-1 parasite density. Models comparing parasite density at non-baseline visits adjusted for baseline SBP-1 values. A value of 0.001 was added to all values to account for zeroes
² Calculated by 100 * (10^MD − 1)

ISSN: 1475-2875