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|
Infection Type
|
Prevalence, n (%)
|
Ring-stage parasite density (per μL), median [IQR]
|
|---|
|
Day 7
|
p-value
|
Day 14
|
p-value
|
Day 28
|
p-value
|
|---|
|
Treatment success
|
63 (86)
|
0 [0, 0.07]
|
Ref
|
0 [0, 0]
|
Ref
|
0 [0, 0]
|
Ref
|
|
Recurrent
|
10 (14)
|
0 [0, 0]
|
0.99
|
0.08 [0, 0.4]
|
0.011
|
0 [0, 0.3]
|
0.068
|
|
Recrudescent
|
4 (5)
|
0 [0, 6.5]
|
0.57
|
5.6 [0,11.2]
|
0.12
|
14.2 [0, 28.4]
|
0.029
|
|
Re-infection
|
4 (5)
|
0 [0, 0.4]
|
0.92
|
0.08 [0, 0.2]
|
0.085
|
0 [0, 0]
|
0.61
|
|
Indeterminate
|
2 (3)
|
0 [0, 0]
|
0.40
|
0.3 [0, 0.7]
|
0.12
|
0.1 [0, 0.3]
|
0.041
|
- To assess whether prior ring-stage parasite densities were associated with increased risk of recurrent infections, parasite densities for each column of recurrent infections excludes those that were detected before or on that day of follow-up. For example, ring-stage parasite densities for recrudescent infections on day 14 excludes recrudescent infections that occurred on day 7 (n = 1) and day 14 (n = 1)
- p-values were computed using the Mann–Whitney test. Comparisons are between recurrent infection categories to reference category (Treatment Success)
