Table 1 30-day survival analysis of Plasmodium berghei-infected mice after treatment with either xylopic acid, artesunate, amodiaquine, or artemether/lumefantrine
| Treatment (mg/kg) | Median survival (days) | Hazard ratio (log-rank) | p-value |
|---|---|---|---|
| Naïve | 30 | – | – |
| Sham | 11 | ||
| XA | |||
| 3 | 14 | 0.49 | 0.2017 |
| 10 | 15 | 0.49 | 0.2017 |
| 30 | 21 | 0.15 | 0.0269* |
| 100 | 17 | 0.46 | 0.1401 |
| 150 | 17 | 0.32 | 0.0272* |
| ART | |||
| 1 | 12 | 0.84 | 0.7501 |
| 2 | 15 | 0.51 | 0.2088 |
| 4 | 17 | 0.39 | 0.0689 |
| 8 | 18 | 0.25 | 0.0064** |
| 16 | 24 | 0.20 | 0.0064** |
| AQ | |||
| 1.25 | 15 | 0.47 | 0.1843 |
| 2.5 | 15 | 0.48 | 0.1842 |
| 5 | 16 | 0.53 | 0.2097 |
| 10 | 23 | 0.25 | 0.0064** |
| 20 | 16 | 0.40 | 0.0812 |
| AL | 26 | 0.20 | 0.0018** |